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Guthrie's is a popular American comfort food restaurant located in Tuscaloosa. The menu features a variety of dishes including burgers, sandwiches, salads, and entrees such as steak and seafood. They are known for their homemade recipes and use of fresh ingredients.

Their burger selection includes classic options like cheeseburgers and bacon cheeseburgers, as well as more unique choices like the "Guthrie's" with two patties and three types of cheese. They also offer a variety of sandwiches, including club sandwiches and chicken parmesan.

In addition to their main courses, Guthrie's offers a range of sides and appetizers. These include onion rings, fries, and fried pickles, as well as more substantial items like salads and soup bowls. Their menu is designed to cater to a wide range of tastes and dietary needs.

Guthrie's has received positive reviews from local diners, praising the quality and value of their meals. The restaurant's casual atmosphere makes it a popular choice for families and groups.